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Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站
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A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia.
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
。 New Delhi, Oct 17 (UNI) Prime Minister Narendra Modi on Monday kickstarted the distribution of Pradhan Mantri Jan Arogya Yojana - Mukhyamantri Amrutam, (PMJAY-MA) Ayushman cards in Gujarat via video conferencing.
"The Pradhan Mantri Jan Arogya Yojana - Mukhyamantri Amrutam, (PMJAY-MA) Ayushman cards will ensure top quality and affordable medical care," he said.
Referring to the spirit of 'Sarve Santu Niramaya' (May all be free of diseases), the Prime Minister said Ayushman Yojana aims for health for all.
He appreciated the enormity of the campaign of distributing 50 lakh cards to the people in the state.
"This bears testimony to the sensitivity of the Gujarat Government. We have been hearing about health insurance in many countries of the world but India is going beyond that, ensuring health assurance," he said.
"In the earlier governments, schemes for the benefit of the common man had become a mere formality. The money that was spent on these schemes was done keeping in mind a particular area and political interests. It was necessary to change this situation and we took the lead in this change. Today when planning is done, we first study the condition of common citizens and study their needs," he said.
The Prime Minister also interacted with the beneficiaries of PMJAY-MA Yojana Ayushman cards.
Interacting with Piyushbhai from Tuwar in Banaskantha, the Prime Minister enquired about his family and his recent health conditions. The Prime Minister was happy to know that the Ayushman Bharat scheme had given him a new lease on life. Modi assured him that the government will always take care of everyone like him.
The Prime Minister interacted with Shri Damor Lalabhai Somabhai from Mahisagar and inquired if his cancer treatment went through well.
UNI ASU SHK2258。
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